Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556306 | 0.90 | ATM (0.54) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL6556305 | 0.90 | ATM (0.54) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL8606837 | 0.90 | CMA1 (0.51) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL7355735 | 0.86 | KLK5 (0.56) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL7355740 | 0.86 | KLK5 (0.56) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL9081107 | 0.85 | REN (0.49) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL6556253 | 0.83 | KLK5 (0.53) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL6556246 | 0.83 | KLK5 (0.53) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL6558292 | 0.83 | KLK5 (0.48) | RENKLK5CTSSCTSKCTSL | |
| SCHEMBL7422374 | 0.82 | BCL2 (0.49) | RENKLK5ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826671-B1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2004-12-29 | — | — | EP | disclosed |