Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.49 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556439 | 1.00 | KLK5 (0.55) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8736231 | 0.91 | BCL2 (0.49) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7355740 | 0.88 | KLK5 (0.56) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7355735 | 0.88 | KLK5 (0.56) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7152790 | 0.87 | TRPM8 (0.54) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL7320400 | 0.87 | TRPM8 (0.54) | CTSSCTSKCTSLCTSBSYK | |
| SCHEMBL6556246 | 0.85 | KLK5 (0.53) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6556253 | 0.85 | KLK5 (0.53) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1612669 | 0.83 | KLK5 (0.59) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22287999 | 0.83 | KLK5 (0.42) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826671-B1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2004-12-29 | — | — | EP | disclosed |
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0826671-A1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | THE GREEN CROSS CORPORATION (JP) | 1998-03-04 | — | — | EP | disclosed |
| EP-0218688-B1 | DIHALO-STATINE SUBSTITUTED RENIN INHIBITORS | THE UPJOHN COMPANY (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4882420-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0218688-A1 | DIHALO-STATINE SUBSTITUTED RENIN INHIBITORS. | UPJOHN CO (US) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986006379-A1 | DIHALO-STATINE SUBSTITUTED RENIN INHIBITORS | THE UPJOHN COMPANY (US) | 1986-11-06 | — | — | WO | disclosed |