Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | YAP1 | P46937 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556436 | 0.91 | KLK5 (0.55) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL6556439 | 0.91 | KLK5 (0.55) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL7331235 | 0.90 | BCL2 (0.55) | BCL2PTPN1KLK5RENLTA4H | |
| SCHEMBL7422374 | 0.86 | BCL2 (0.49) | BCL2PTPN1KLK5REN | |
| SCHEMBL7152790 | 0.84 | TRPM8 (0.54) | — | |
| SCHEMBL7320400 | 0.84 | TRPM8 (0.54) | — | |
| SCHEMBL8945503 | 0.84 | REN (0.49) | BCL2PTPN1KLK5RENLTA4H | |
| SCHEMBL8093075 | 0.84 | PPARA (0.48) | BCL2PTPN1KLK5RENLTA4H | |
| SCHEMBL8945512 | 0.82 | REN (0.47) | BCL2PTPN1KLK5RENLTA4H | |
| SCHEMBL8945614 | 0.82 | REN (0.47) | BCL2PTPN1KLK5RENLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716973-A | ADMINISTERING DIFLUORO STATONE ANALOGS | MERRELL PHARMACEUTICALS INC. (US) | 1998-02-10 | — | — | US | disclosed |