Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | FNTA | P49354 | 11/20 | 0.41 |
| ▸ | FNTB | P49356 | 11/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095527 | 0.83 | IDO1 (0.44) | IDO1FNTAFNTBMAPK1PGGT1B | |
| SCHEMBL7094385 | 0.80 | IDO1 (0.48) | IDO1FNTAFNTBMAPK1GSK3B | |
| SCHEMBL7645793 | 0.76 | FNTA (0.47) | IDO1FNTAFNTBMAPK1KCNH2 | |
| SCHEMBL7645087 | 0.75 | IDO1 (0.44) | IDO1FNTAFNTBKCNH2PGGT1B | |
| SCHEMBL7089979 | 0.74 | RORC (0.41) | IDO1GSK3BDYRK1A | |
| SCHEMBL7217940 | 0.73 | FNTA (0.39) | IDO1FNTAFNTBKCNH2 | |
| SCHEMBL7643836 | 0.73 | FNTA (0.47) | IDO1FNTAFNTBPGGT1B | |
| SCHEMBL7087668 | 0.72 | IDO1 (0.39) | IDO1FNTAFNTBMAPK1GSK3B | |
| SCHEMBL7092213 | 0.71 | IDO1 (0.39) | IDO1GSK3BDYRK1AKCNH2 | |
| SCHEMBL7210392 | 0.70 | IDO1 (0.52) | IDO1FNTAFNTBMAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390033-A1 | FARNESYL PROTEIN TRANSFERASE INHIBITORS FOR TREATING CACHEXIA | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002085364-A1 | FARNESYL PROTEIN TRANSFERASE INHIBITORS FOR TREATING CACHEXIA | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-10-31 | — | — | WO | disclosed |