Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | HTR2B | P41595 | 4/20 | 0.54 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556629 | 1.00 | SIGMAR1 (0.54) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6556395 | 0.83 | KDM4E (0.42) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6556389 | 0.83 | KDM4E (0.42) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6557750 | 0.81 | DRD2 (0.43) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6557759 | 0.81 | DRD2 (0.43) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6556308 | 0.79 | KMT2A (0.42) | ACHEALDH1A1KMT2A | |
| SCHEMBL6556631 | 0.79 | KMT2A (0.42) | ACHEALDH1A1KMT2A | |
| SCHEMBL6556304 | 0.79 | KMT2A (0.42) | ACHEALDH1A1KMT2A | |
| SCHEMBL6556627 | 0.79 | KMT2A (0.42) | ACHEALDH1A1KMT2A | |
| SCHEMBL1895840 | 0.78 | DRD2 (0.53) | SIGMAR1DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | claimed |
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |