Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556719 | 0.87 | ALDH1A1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6556741 | 0.77 | MAPT (0.59) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6557047 | 0.76 | SLC2A1 (0.46) | MAPTSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL10118253 | 0.76 | MAPT (0.68) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6558728 | 0.73 | ALDH1A1 (0.43) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6556759 | 0.73 | TRPV1 (0.52) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL116096 | 0.71 | EPHX1 (0.66) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4894719 | 0.71 | EPHX1 (0.66) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6558698 | 0.71 | SLC2A1 (0.41) | MAPTNPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6556784 | 0.71 | ALDH1A1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100483-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2004-09-29 | — | — | EP | claimed |
| US-6166013-A | Glucocortiocoid-selective agents | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |