SCHEMBL6556874

SCHEMBL6556874

CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccccc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 2/20 0.54
CTSK P43235 2/20 0.54
CA2 P00918 1/20 0.50
KLK5 Q9Y337 1/20 0.48
ALDH1A1 P00352 4/20 0.48
KDM4E B2RXH2 3/20 0.48
MAPT P10636 1/20 0.48
TSHR P16473 2/20 0.47
HPGD P15428 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
KLK7 P49862 1/20 0.46
EPHX2 P34913 1/20 0.46
BACE1 P56817 3/20 0.45
MEN1 O00255 1/20 0.45
LMNA P02545 1/20 0.45
KMT2A Q03164 1/20 0.45
HSD17B10 Q99714 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6555173 0.87 CTSS (0.52) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL8780275 0.84 CTSS (0.59) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL7414154 0.84 CTSS (0.61) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL7414151 0.84 CTSS (0.61) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL23975809 0.84 CTSS (0.61) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL6555098 0.82 CTSS (0.56) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL9476654 0.81 CTSS (0.53) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL6555039 0.81 HDAC4 (0.55) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL6555028 0.79 KDM4E (0.56) CTSSCTSKCA2KLK5ALDH1A1
SCHEMBL11036298 0.78 HDAC4 (0.53) CTSSCTSKCA2KLK5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0797447-B1 HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES UNIV ARIZONA (US) 2004-03-03 EP disclosed
EP-0797447-A4 HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES UNIV ARIZONA (US) 1999-09-29 EP disclosed
EP-0797447-A1 HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES ARIZONA BOARD OF REGENTS (US) 1997-10-01 EP disclosed
US-5663149-A ANTICARCINOGENIC AGENTS RELATED TO DOLASTATIN ARIZONA BOARD OF REGENTS ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 1997-09-02 US disclosed
WO-1996018408-A1 HUMAN CANCER INHIBITORY PENTAPEPTIDE HETEROCYCLIC AND HALOPHENYL AMIDES ARIZONA BOARD OF REGENTS (US) 1996-06-20 WO disclosed