Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | SUV39H2 | Q9H5I1 | 6/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1352103 | 1.00 | MTNR1A (0.49) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL6557127 | 1.00 | MTNR1A (0.49) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL30880018 | 0.93 | MAP4K4 (0.49) | KDM4DPDE10A | |
| SCHEMBL1350899 | 0.87 | GPR119 (0.58) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL1350901 | 0.87 | GPR119 (0.58) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL32665586 | 0.87 | MTNR1A (0.50) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL1800785 | 0.87 | SUV39H2 (0.54) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL6559433 | 0.87 | GPR119 (0.58) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL32665576 | 0.87 | MTNR1A (0.50) | MTNR1AMTNR1BSUV39H2PIM1PIM3 | |
| SCHEMBL29689683 | 0.87 | NOTUM (0.57) | MTNR1AMTNR1BSUV39H2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392651-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090326-A1 | HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |