Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6350486 | 0.98 | PNMT (0.35) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL6648710 | 0.90 | PNMT (0.33) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL6557762 | 0.86 | PNMT (0.33) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL6295596 | 0.83 | PNMT (0.33) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL6653985 | 0.83 | PNMT (0.30) | PNMT | |
| SCHEMBL7560364 | 0.83 | PNMT (0.35) | PNMTNPC1RAB9A | |
| SCHEMBL6652360 | 0.83 | PNMT (0.32) | PNMT | |
| SCHEMBL6557648 | 0.82 | PNMT (0.34) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27331225 | 0.82 | PNMT (0.34) | PNMTNPC1RAB9A | |
| SCHEMBL27669413 | 0.82 | PNMT (0.34) | PNMTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705851-B9 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-0705851-B1 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-01-21 | — | — | EP | disclosed |
| US-5710224-A | CATALYTIC POLYMERIZATION OF ETHYLENE USING FLUORENE INDENYL ETHANE ZIRCONIUM DICHLORIDE WITH METALLOCENE | PHILLIPS PETROLEUM COMPANY (US) | 1998-01-20 | — | — | US | disclosed |
| US-5594078-A | BRIDGED FLUORENYL METALLOCENE CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0729978-A1 | Polyethylene and method for production thereof | PHILLIPS PETROLEUM COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5534473-A | METALLOCENES AND COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-07-09 | — | — | US | disclosed |
| EP-0705851-A2 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | PHILLIPS PETROLEUM COMPANY (US) | 1996-04-10 | — | — | EP | disclosed |