Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 19/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | TSHR | P16473 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19692701 | 0.89 | CYP3A4 (0.58) | CYP3A4ALDH1A1TSHRMAPTMAPK1 | |
| SCHEMBL4998172 | 0.87 | CTRB1 (0.55) | CYP3A4ALDH1A1TSHRLMNA | |
| SCHEMBL4665558 | 0.87 | CTRB1 (0.55) | CYP3A4ALDH1A1TSHRLMNA | |
| SCHEMBL7134978 | 0.87 | CTRB1 (0.55) | CYP3A4ALDH1A1TSHRLMNA | |
| SCHEMBL1554807 | 0.86 | ATM (0.64) | CYP3A4ALDH1A1TSHRTP53 | |
| SCHEMBL12195401 | 0.86 | CTSK (0.49) | MAPTLMNA | |
| SCHEMBL12195405 | 0.85 | KLK1 (0.58) | ALDH1A1TP53LMNA | |
| SCHEMBL21399728 | 0.85 | CYP3A4 (0.64) | CYP3A4ALDH1A1TSHRMAPTMAPK1 | |
| SCHEMBL16553624 | 0.83 | CTRB1 (0.49) | ALDH1A1TP53LMNA | |
| SCHEMBL29944675 | 0.83 | TP53 (0.60) | ALDH1A1MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391454-A1 | Substituted benzamide compounds with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1195372-A1 | N-heterocyclic substituted benzamide derivatives with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6156766-A | Benzamide compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| US-5958944-A | TREATMENT OF CIRCULATORY DISEASES IN CORONARY, CEREBRAL, RENAL AND PERIPHERAL ARTERIES, AS A THERAPEUTIC AGENT FOR HYPERTENSION, ANGINA PECTORIS, AND RENAL AND PERIPHERAL CIRCULATION DISORDER, ANTIASTHMATIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0757038-A1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |