Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.62 |
| ▸ | PLAU | P00749 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | TNKS | O95271 | 2/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.52 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.52 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991841 | 0.88 | HDAC1 (0.64) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| Benzyl Benzylcarbamate SCHEMBL1136818 | 0.87 | PLAU (0.70) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| Benzyl Benzylcarbamate SCHEMBL19810513 | 0.86 | PLAU (0.68) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| Benzyl Benzylcarbamate SCHEMBL9998166 | 0.86 | PLAU (0.68) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| Benzyl Benzylcarbamate SCHEMBL28413454 | 0.86 | PLAU (0.68) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| SCHEMBL6558232 | 0.86 | SMN1; SMN2 (0.58) | HDAC1HDAC2HDAC3LMNASMN1; SMN2 | |
| SCHEMBL5931079 | 0.85 | PLAU (0.69) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| SCHEMBL993696 | 0.85 | HDAC1 (0.62) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| SCHEMBL28071194 | 0.85 | PLAU (0.64) | HDAC1HDAC2HDAC3PLAUNAMPT | |
| SCHEMBL191161 | 0.84 | PLAU (0.68) | HDAC1HDAC2HDAC3PLAUNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| EP-1391454-A1 | Substituted benzamide compounds with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1195372-A1 | N-heterocyclic substituted benzamide derivatives with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6156766-A | Benzamide compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| US-5958944-A | TREATMENT OF CIRCULATORY DISEASES IN CORONARY, CEREBRAL, RENAL AND PERIPHERAL ARTERIES, AS A THERAPEUTIC AGENT FOR HYPERTENSION, ANGINA PECTORIS, AND RENAL AND PERIPHERAL CIRCULATION DISORDER, ANTIASTHMATIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0757038-A1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |