Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.58 |
| ▸ | CIT | O14578 | 5/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.58 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PRKCB | P05771 | 1/20 | 0.58 |
| ▸ | PRKCA | P17252 | 1/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | MARK3 | P27448 | 1/20 | 0.58 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557931 | 0.86 | ROCK2 (0.56) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL6558091 | 0.83 | PRKCQ (0.39) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL6559132 | 0.81 | ROCK2 (0.58) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL6558233 | 0.79 | CIT (0.71) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL2771542 | 0.77 | ROCK2 (0.69) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL17181745 | 0.76 | ROCK2 (0.64) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL4772895 | 0.76 | ROCK2 (0.67) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL6558074 | 0.75 | ROCK2 (0.53) | ROCK2CITROCK1PRKD3PRKACA | |
| SCHEMBL6557863 | 0.75 | ROCK2 (0.56) | ROCK2CITROCK1PRKD3PRKACA | |
| Hydrochloric Acid SCHEMBL30976603 | 0.75 | ROCK2 (0.67) | ROCK2CITROCK1PRKD3PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391454-B1 | Substituted benzamide compounds with antihypertensive activity | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1391454-A1 | Substituted benzamide compounds with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1195372-A1 | N-heterocyclic substituted benzamide derivatives with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6156766-A | Benzamide compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| EP-0757038-A1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |