Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.39 |
| ▸ | CNR2 | P34972 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069945 | 0.79 | CNR1 (0.56) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL4089479 | 0.69 | CNR1 (0.52) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL31318122 | 0.69 | CNR1 (0.52) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL3176889 | 0.69 | CNR1 (0.52) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL9700209 | 0.68 | CNR1 (0.46) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7024508 | 0.67 | CNR1 (0.42) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL5792357 | 0.66 | CNR1 (0.55) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL31318123 | 0.66 | CNR1 (0.55) | CNR1CNR2CYP3A4CYP2C9MEN1 | |
| SCHEMBL8075187 | 0.64 | LMNA (0.46) | CNR1CNR2MEN1KMT2AMAPT | |
| SCHEMBL8061084 | 0.63 | LMNA (0.44) | CNR1CNR2ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490111-A2 | EDG-RECEPTOR AGONISTS FOR THE TREATMENT OF HYPERTENSION | Solvay Pharmaceuticals GmbH (DE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003051395-A2 | EDG-RECEPTOR AGONIST FOR THE TREATMENT OF HYPERTENSION | SOLVAY PHARMACEUTICALS GMBH (DE) | 2003-06-26 | — | — | WO | disclosed |