Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558458 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1GAAMAPTALOX15 | |
| SCHEMBL6558466 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1GAAMAPTALOX15 | |
| Fumaric Acid SCHEMBL6556397 | 0.91 | KMT2A (0.40) | KDM4EALDH1A1GAAMAPTALOX15 | |
| Fumaric Acid SCHEMBL6556402 | 0.91 | KMT2A (0.40) | KDM4EALDH1A1GAAMAPTALOX15 | |
| Fumaric Acid SCHEMBL6556387 | 0.91 | KMT2A (0.40) | KDM4EALDH1A1GAAMAPTALOX15 | |
| Fumaric Acid SCHEMBL6556392 | 0.91 | KMT2A (0.40) | KDM4EALDH1A1GAAMAPTALOX15 | |
| SCHEMBL6556481 | 0.89 | GAA (0.45) | KDM4EALDH1A1GAAMAPTALOX15 | |
| SCHEMBL6556478 | 0.89 | GAA (0.45) | KDM4EALDH1A1GAAMAPTALOX15 | |
| SCHEMBL6556471 | 0.89 | GAA (0.45) | KDM4EALDH1A1GAAMAPTALOX15 | |
| SCHEMBL6556584 | 0.88 | SIGMAR1 (0.47) | KDM4EALDH1A1MAPTALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | claimed |
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |