Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.37 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6556402 | 1.00 | KMT2A (0.40) | KMT2AMEN1HTTL3MBTL1GAA | |
| Fumaric Acid SCHEMBL6556392 | 1.00 | KMT2A (0.40) | KMT2AMEN1HTTL3MBTL1GAA | |
| Fumaric Acid SCHEMBL6556387 | 1.00 | KMT2A (0.40) | KMT2AMEN1HTTL3MBTL1GAA | |
| Fumaric Acid SCHEMBL6556374 | 0.91 | GAA (0.44) | KMT2AMEN1HTTL3MBTL1GAA | |
| Fumaric Acid SCHEMBL6556381 | 0.91 | GAA (0.44) | KMT2AMEN1HTTL3MBTL1GAA | |
| Fumaric Acid SCHEMBL6556377 | 0.91 | GAA (0.44) | KMT2AMEN1HTTL3MBTL1GAA | |
| Fumaric Acid SCHEMBL6556369 | 0.91 | GAA (0.44) | KMT2AMEN1HTTL3MBTL1GAA | |
| SCHEMBL6558462 | 0.91 | KDM4E (0.42) | L3MBTL1GAASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6558466 | 0.91 | KDM4E (0.42) | L3MBTL1GAASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6558458 | 0.91 | KDM4E (0.42) | L3MBTL1GAASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |