Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.48 |
| ▸ | FEN1 | P39748 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29025711 | 0.86 | POLB (0.45) | ALDH1A1MAPK1HIF1AP2RX7ERCC5 | |
| SCHEMBL30356468 | 0.84 | POLB (0.58) | ALDH1A1ERCC5FEN1MAPTKDM4E | |
| SCHEMBL1682664 | 0.84 | POLB (0.58) | ALDH1A1ERCC5FEN1MAPTKDM4E | |
| SCHEMBL16411136 | 0.81 | ALDH1A1 (0.59) | ALDH1A1MAPK1HIF1AP2RX7ERCC5 | |
| SCHEMBL30356525 | 0.81 | POLB (0.46) | ALDH1A1MAPK1HIF1AP2RX7MAPT | |
| SCHEMBL6556649 | 0.80 | MAPT (0.48) | ALDH1A1P2RX7ERCC5FEN1MAPT | |
| SCHEMBL30356530 | 0.80 | POLB (0.42) | ALDH1A1MAPK1HIF1AP2RX7MAPT | |
| SCHEMBL29025627 | 0.80 | POLB (0.42) | ALDH1A1MAPK1HIF1AP2RX7MAPT | |
| SCHEMBL30356535 | 0.79 | POLB (0.46) | ALDH1A1MAPTKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL29025637 | 0.79 | POLB (0.46) | ALDH1A1MAPTKDM4EPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003505-B1 | HETEROCYCLIC VINYLETHERS AGAINST NEUROLOGICAL DISORDERS | HOFFMANN LA ROCHE (CH) | 2004-03-24 | — | — | EP | disclosed |
| US-6248901-B1 | (1-PHENYL-2-CYCLOALKYLOXY-VINYL)-(1,2,4)TRIAZOLES; CONTROL OR PREVENTION OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS. | HOFFMAN-LA ROCHE INC. | 2001-06-19 | — | — | US | disclosed |
| EP-1003505-A1 | HETEROCYCLIC VINYLETHERS AGAINST NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-31 | — | — | EP | disclosed |
| US-6054588-A | Heterocyclic vinyl ethers | HOFFMAN-LA ROCHE INC. (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1999008678-A1 | HETEROCYCLIC VINYLETHERS AGAINST NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-25 | — | — | WO | disclosed |