Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MIF | P14174 | 2/20 | 0.46 |
| ▸ | BCKDK | O14874 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPM2A | O95278 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18261966 | 0.88 | KDM4E (0.47) | KDM4EMIFNPC1MAPTRAB9A | |
| SCHEMBL30593470 | 0.88 | KDM4E (0.47) | KDM4EMIFNPC1MAPTRAB9A | |
| SCHEMBL15989734 | 0.86 | MIF (0.43) | KDM4EMIFBCKDKMCL1RXFP1 | |
| SCHEMBL28529352 | 0.84 | KDM4E (0.46) | KDM4EMIFNPC1MAPTRAB9A | |
| SCHEMBL29466898 | 0.84 | KDM4E (0.48) | KDM4EMIFNPC1MAPTRAB9A | |
| SCHEMBL5019781 | 0.84 | KDM4E (0.48) | KDM4EMIFNPC1MAPTRAB9A | |
| SCHEMBL13135167 | 0.81 | KDM4E (0.54) | KDM4EMIFNPC1MAPTRAB9A | |
| SCHEMBL30406558 | 0.81 | MIF (0.46) | KDM4EMIFBCKDKMCL1RXFP1 | |
| SCHEMBL4919520 | 0.81 | MIF (0.46) | KDM4EMIFBCKDKMCL1RXFP1 | |
| SCHEMBL29450780 | 0.81 | KDM4E (0.50) | KDM4EMIFALDH1A1L3MBTL1EPM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294687-A2 | 1,2,4-TRISUBSTITUTED BENZENES AS INHIBITORS OF 15-LIPOXYGENASE | WARNER-LAMBERT COMPANY (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001096298-A2 | 1,2,4-TRISUBSTITUTED BENZENES AS INHIBITORS OF 15-LIPOXYGENASE | WARNER-LAMBERT COMPANY (US) | 2001-12-20 | — | — | WO | claimed |
| EP-1197491-B1 | Thioxanthenone antitumor agents | SANOFI AVENTIS (FR) | 2004-12-29 | — | — | EP | disclosed |
| CN-1178651-C | Lyophilized thioxanthenone anti-tumor angents | ʥŵ��-�ϳ�ʵ����(����)����˾ | 2004-12-08 | — | — | CN | disclosed |
| EP-0917458-B1 | LYOPHILIZED THIOXANTHENONE ANTIMUMOR AGENTS | SANOFI SYNTHELABO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-0882723-B1 | Thioxanthenone antitumor agents | SANOFI SYNTHELABO (FR) | 2002-07-31 | — | — | EP | disclosed |
| EP-1197491-A1 | Thioxanthenone antitumor agents | SANOFI-SYNTHELABO (FR) | 2002-04-17 | — | — | EP | disclosed |
| EP-0619315-B1 | Thioxanthenone antitumor agents | SANOFI SA (FR) | 1999-06-09 | — | — | EP | disclosed |
| EP-0917458-A1 | LYOPHILIZED THIOXANTHENONE ANTIMUMOR AGENTS | SANOFI (FR) | 1999-05-26 | — | — | EP | disclosed |
| EP-0882723-A1 | Thioxanthenone antitumor agents | SANOFI (FR) | 1998-12-09 | — | — | EP | disclosed |
| CN-1201387-A | Lyophilized thioxanthone antitumor agents | SANOFI MEDICINES CO (FR) | 1998-12-09 | — | — | CN | disclosed |
| US-5665760-A | Lyophilized thioxanthenone antitumor agents | SANOFI WINTHROP, INC. (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997010809-A1 | LYOPHILIZED THIOXANTHENONE ANTIMUMOR AGENTS | SANOFI (FR) | 1997-03-27 | — | — | WO | disclosed |
| US-5380749-A | Thioxanthenone antitumor agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0619315-A1 | Thioxanthenone antitumor agents | STERLING WINTHROP INC. (US) | 1994-10-12 | — | — | EP | disclosed |
| US-5346917-A | For mammals | STERLING WINTHROP INC. (US) | 1994-09-13 | — | — | US | disclosed |