Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL6560927 | 0.88 | LMNA (0.64) | LMNAMAPTPOLBHPGDXBP1 | |
| SCHEMBL97377 | 0.88 | LMNA (0.68) | LMNAMAPTPOLBHPGDXBP1 | |
| SCHEMBL9178337 | 0.88 | LMNA (0.68) | LMNAMAPTPOLBHPGDXBP1 | |
| SCHEMBL6559696 | 0.87 | LMNA (0.64) | LMNAMAPTPOLBHPGDXBP1 | |
| Ammonia Solution, Strong SCHEMBL28834669 | 0.86 | LMNA (0.65) | LMNAMAPTPOLBHPGDXBP1 | |
| Methylamine SCHEMBL28036850 | 0.84 | LMNA (0.63) | LMNAMAPTPOLBHPGDXBP1 | |
| SCHEMBL1618880 | 0.84 | LMNA (1.00) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL50453 | 0.84 | LMNA (1.00) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| Propane SCHEMBL27634743 | 0.84 | LMNA (0.63) | LMNAMAPTPOLBHPGDXBP1 | |
| SCHEMBL3254859 | 0.84 | LMNA (1.00) | LMNACYP2D6ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0735403-B1 | Liquid crystal orienting agent | JSR CORP (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-5700860-A | Liquid crystal orienting agent | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1997-12-23 | — | — | US | disclosed |
| EP-0735403-A1 | Liquid crystal orienting agent | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1996-10-02 | — | — | EP | disclosed |