Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5853041 | 0.84 | GSK3B (0.31) | — | |
| SCHEMBL8343111 | 0.83 | MAPT (0.33) | MAPT | |
| SCHEMBL6966027 | 0.82 | XIAP (0.33) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6957035 | 0.81 | KCNA5 (0.35) | — | |
| SCHEMBL8109045 | 0.81 | PDE2A (0.32) | — | |
| SCHEMBL6559757 | 0.80 | TDP1 (0.36) | TYMSDHFR | |
| SCHEMBL6560668 | 0.80 | KDM4E (0.31) | MAPT | |
| SCHEMBL7086758 | 0.80 | CHRNB2 (0.30) | — | |
| SCHEMBL8346651 | 0.78 | HSP90B1 (0.32) | TYMSDHFR | |
| SCHEMBL14001863 | 0.77 | HSP90B1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462608-B2 | Non nucleoside reverse transcriptase inhibitors | GILEAD SCIENCES, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| EP-0994106-B1 | PROCESS FOR THE PREPARATION OF CARBAMOYLATED IMIDAZOLE DERIVATIVES | SHIONOGI & CO (JP) | 2004-03-17 | — | — | EP | disclosed |
| EP-0994106-A1 | PROCESS FOR THE PREPARATION OF CARBAMOYLLATED IMIDAZOLE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |
| US-6018049-A | Process for the preparation of carbamoylated imidazole derivatives | SHIONOGI & CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |