SCHEMBL6559190

SCHEMBL6559190

CCCc1c(OCCCSc2ccc(CC(=O)OC)cc2Cl)ccc2c1ccn2-c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 12/20 0.52
PPARG P37231 11/20 0.52
PPARA Q07869 10/20 0.52
NR1H2 P55055 4/20 0.48
NR1H3 Q13133 4/20 0.48
KCNH2 Q12809 1/20 0.34
MAPT P10636 3/20 0.34
THRB P10828 1/20 0.34
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
ATM Q13315 1/20 0.33
CNR2 P34972 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6561529 0.92 PPARD (0.62) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6559843 0.84 PPARD (0.60) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6934160 0.78 PPARG (0.74) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL7042280 0.77 PPARG (0.65) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6939101 0.77 PPARG (0.73) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6936015 0.77 PPARG (0.76) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6560732 0.77 PPARD (0.53) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6937386 0.77 PPARG (0.84) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6560656 0.76 PPARD (0.85) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6933762 0.76 PPARG (0.69) PPARDPPARGPPARANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0904079-B1 ANTIDIABETIC AGENTS MERCK & CO INC (US) 2004-03-24 EP disclosed
EP-0904079-A4 1999-05-06 EP disclosed
EP-0904079-A1 ANTIDIABETIC AGENTS Merck & Co., Inc. (US) 1999-03-31 EP disclosed
US-5859051-A ACETYLPHENOL DERIVATIVES MERCK & CO., INC. (US) 1999-01-12 US disclosed
WO-1997027857-A1 ANTIDIABETIC AGENTS MERCK & CO., INC. (US) 1997-08-07 WO disclosed