Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.47 |
| ▸ | PPARD | Q03181 | 10/20 | 0.40 |
| ▸ | PPARA | Q07869 | 9/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041401 | 0.80 | HPSE (0.43) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6932993 | 0.79 | PPARG (0.49) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL6559946 | 0.73 | PPARD (0.72) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8666064 | 0.73 | PPARD (0.44) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL7046131 | 0.72 | PPARG (0.73) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6559176 | 0.71 | PPARG (0.49) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8443121 | 0.69 | KDM1A (0.43) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL7039487 | 0.69 | PPARD (0.42) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL8441098 | 0.68 | PPARG (0.65) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL7040305 | 0.67 | NR1H3 (0.81) | PPARGPPARDPPARANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | claimed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | claimed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | claimed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |