Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557373 | 0.87 | TDP1 (0.52) | ALDH1A1HSD17B10TDP1MAPTHTR2A | |
| SCHEMBL6557376 | 0.87 | TDP1 (0.52) | ALDH1A1HSD17B10TDP1MAPTHTR2A | |
| SCHEMBL28814169 | 0.75 | ALDH1A1 (0.44) | ALDH1A1HSD17B10TDP1HTR2AKCNH2 | |
| SCHEMBL1373939 | 0.74 | HCAR2 (0.57) | ALDH1A1HSD17B10TDP1MAPTMAOB | |
| SCHEMBL1375276 | 0.74 | HCAR2 (0.57) | ALDH1A1HSD17B10TDP1MAPTMAOB | |
| SCHEMBL7224762 | 0.73 | MAOB (0.44) | ALDH1A1HSD17B10TDP1MAOBKDM4E | |
| SCHEMBL14533597 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HSD17B10TDP1MAPTKDM4E | |
| SCHEMBL651902 | 0.72 | ALDH1A1 (0.71) | ALDH1A1HSD17B10TDP1LMNA | |
| SCHEMBL351760 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HSD17B10TDP1PTGS2KDM4E | |
| SCHEMBL6559059 | 0.71 | ALDH1A1 (0.33) | ALDH1A1HSD17B10TDP1HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916394-B1 | Method of manufacturing modified particles and manufacturing device therefor | SHARP KK (JP) | 2004-03-10 | — | — | EP | disclosed |
| US-6194487-B1 | EXPOSURE OF PARTICLES TO SUPERSATURATED VAPOR OF MONOMERS, CONDENSATION AND POLYMERIZATION ON THE SURFACE | SHARP KABUSHIKI KAISHA (JP) | 2001-02-27 | — | — | US | disclosed |
| EP-0916394-A2 | Method of manufacturing modified particles and manufacturing device therefor | Sharp Kabushiki Kaisha (JP) | 1999-05-19 | — | — | EP | disclosed |