Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 10/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30888694 | 1.00 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL29920860 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL6559398 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL31393622 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL10444308 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL3262766 | 0.78 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL6560861 | 0.78 | ALDH1A1 (0.37) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL6560858 | 0.78 | ALDH1A1 (0.37) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL8069752 | 0.78 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTMAOBGAA | |
| SCHEMBL6559560 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTMAOBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| US-6071953-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-06-06 | — | — | US | disclosed |
| EP-0860440-A1 | Sulfonamido substituted chromane derivatives with potassium channel blocking activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |