Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13779484 | 0.83 | CYP3A4 (0.36) | CHEK1ENPP2MKNK1MKNK2OGA | |
| SCHEMBL5761153 | 0.79 | OGA (0.37) | OGAHRH3NUDT1 | |
| SCHEMBL12402348 | 0.74 | CYP3A4 (0.37) | CHEK1ENPP2MKNK1MKNK2CYP3A4 | |
| SCHEMBL18708314 | 0.74 | CHEK1 (0.39) | CHEK1ENPP2MKNK1MKNK2CYP3A4 | |
| SCHEMBL9925916 | 0.74 | L3MBTL1 (0.39) | CHEK1ENPP2MKNK1MKNK2CYP3A4 | |
| SCHEMBL18708315 | 0.74 | LMNA (0.43) | CHEK1ENPP2MKNK1MKNK2CYP3A4 | |
| SCHEMBL29956042 | 0.73 | CHEK1 (0.37) | CHEK1ENPP2MKNK1MKNK2CYP3A4 | |
| SCHEMBL31216537 | 0.72 | CHEK1 (0.48) | CHEK1CYP1A2 | |
| SCHEMBL19309238 | 0.72 | LMNA (0.33) | CHEK1CYP3A4CYP11B1CYP11B2LMNA | |
| SCHEMBL3563236 | 0.71 | CHEK1 (0.47) | CHEK1ENPP2MKNK1MKNK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100762-B1 | ERYTHROMYCIN DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZAMBON SPA (IT) | 2004-03-10 | — | — | EP | disclosed |
| US-6468979-B1 | ERYTHROMYCIN DERIVATIVES WITH BIHETEROCYCLIC GROUP AS SUBSTITUENT AT END OF CHAIN HAVE PARTICULARLY BROAD SPECTRUM OF ACTIVITY AND LONG DURATION OF ACTION | ZAMBON GROUP S.P.A. (IT) | 2002-10-22 | — | — | US | disclosed |
| EP-1100762-A2 | ERYTHROMYCIN DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006606-A2 | ERYTHROMYCIN DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2000-02-10 | — | — | WO | disclosed |