Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | PHGDH | O43175 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561321 | 0.89 | KMT2A (0.52) | KMT2AATMPHGDHMEN1ALDH1A1 | |
| SCHEMBL6560465 | 0.88 | MAPT (0.46) | KMT2AATMMEN1ALDH1A1PKM | |
| SCHEMBL6653829 | 0.85 | KMT2A (0.55) | KMT2AATMPHGDHMEN1ALDH1A1 | |
| SCHEMBL6560550 | 0.84 | PHGDH (0.47) | KMT2AATMPHGDHMEN1ALDH1A1 | |
| SCHEMBL7803116 | 0.83 | KMT2A (0.46) | KMT2AATMPHGDHALDH1A1CYP1A2 | |
| SCHEMBL6560562 | 0.80 | LMNA (0.42) | KMT2AATMPHGDHMEN1ALDH1A1 | |
| SCHEMBL6652670 | 0.79 | PHGDH (0.58) | KMT2AATMPHGDHMEN1ALDH1A1 | |
| SCHEMBL8701044 | 0.78 | KMT2A (0.65) | KMT2AATMPHGDHMEN1ALDH1A1 | |
| SCHEMBL6559736 | 0.78 | PHGDH (0.62) | KMT2APHGDHMEN1ALDH1A1CYP1A2 | |
| SCHEMBL6560430 | 0.77 | KMT2A (0.44) | KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100354271-C | Piperazine derivatives and process for the preparation thereof | SAMJIN PHARM CO LTD (KR) | 2007-12-12 | — | — | CN | disclosed |
| EP-1075469-B1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARM CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |
| US-6683184-B2 | ANTITUMOR AGENTS | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2004-01-27 | — | — | US | disclosed |
| US-20030092910-A1 | Piperazine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092910-A1 | Piperazine derivatives and process for the preparation thereof | CBR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | KMT2A 2664/4885ATM 4732/4885PHGDH 2923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.