Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11730704 | 0.78 | CA2 (0.42) | DAOALDH1A1HPGDKDM4E | |
| Silver SCHEMBL11598748 | 0.78 | CES2 (0.39) | DAOHPGD | |
| SCHEMBL19987843 | 0.78 | CES2 (0.39) | DAOHPGD | |
| SCHEMBL17961695 | 0.76 | DAO (0.38) | DAOHPGDUSP2LMNA | |
| SCHEMBL1340077 | 0.76 | — | — | |
| SCHEMBL5246301 | 0.76 | — | — | |
| SCHEMBL77302 | 0.76 | — | — | |
| SCHEMBL3351 | 0.76 | — | — | |
| SCHEMBL5426717 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL3049773 | 0.74 | DAO (0.95) | DAOALDH1A1KMT2APOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952997-B1 | POLYMERIZATION OF OLEFINS | DU PONT (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6613915-B1 | Nickel (II) complexes of certain monoanionic bidentate ligands; pyrrole-2-imine ligand intermediate | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-09-02 | — | — | US | disclosed |
| US-6174975-B1 | ADDITION POLYMERIZATION, CATALYSTS AND COORDINATION COMPOUNDS | E.I. DU PONT DE NEMOURS AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| EP-0952997-A1 | POLYMERIZATION OF OLEFINS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1999-11-03 | — | — | EP | disclosed |
| WO-1998030609-A1 | POLYMERIZATION OF OLEFINS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-07-16 | — | — | WO | disclosed |