SCHEMBL6561683

SCHEMBL6561683

COC(=O)Cc1ccc(OCCC(C)Br)c(Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.49
PPARG P37231 1/20 0.46
PDK2 Q15119 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C19 P33261 1/20 0.44
HPGD P15428 2/20 0.43
NLRP1 Q9C000 1/20 0.43
NPSR1 Q6W5P4 1/20 0.42
ACACB O00763 1/20 0.42
LMNA P02545 2/20 0.41
ATM Q13315 1/20 0.41
CSNK2A1 P68400 2/20 0.41
ALDH1A1 P00352 1/20 0.41
GAA P10253 1/20 0.41
GFER P55789 1/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
MAPK10 P53779 1/20 0.41
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6936400 0.83 MAPT (0.59) MAPTPPARGCYP1A2CYP3A4CYP2C19
SCHEMBL6560014 0.82 MAPT (0.58) MAPTPPARGCYP1A2CYP3A4CYP2C19
SCHEMBL4837941 0.82 MAPT (0.53) MAPTPPARGPDK2CYP1A2CYP3A4
SCHEMBL9307491 0.80 S1PR2 (0.57) MAPTPPARGCYP1A2CYP3A4CYP2C19
SCHEMBL7896877 0.78 ALDH1A1 (0.56) LMNAALDH1A1GAAGFERSMN1; SMN2
SCHEMBL8402476 0.78 LMNA (0.51) MAPTPPARGPDK2HPGDLMNA
SCHEMBL3239979 0.76 MRGPRX4 (0.48) MAPTPPARGPDK2CYP1A2CYP3A4
SCHEMBL10832407 0.75 SMN1; SMN2 (0.54) MAPTPDK2CYP1A2CYP2C19HPGD
SCHEMBL3659539 0.74 MRGPRX4 (0.53) MAPTPDK2CYP1A2CYP3A4CYP2C19
SCHEMBL21820674 0.74 ALDH1A1 (0.48) MAPTHPGDLMNAALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0904079-B1 ANTIDIABETIC AGENTS MERCK & CO INC (US) 2004-03-24 EP disclosed
EP-0904079-A4 1999-05-06 EP disclosed
EP-0904079-A1 ANTIDIABETIC AGENTS Merck & Co., Inc. (US) 1999-03-31 EP disclosed
US-5859051-A ACETYLPHENOL DERIVATIVES MERCK & CO., INC. (US) 1999-01-12 US disclosed
WO-1997027857-A1 ANTIDIABETIC AGENTS MERCK & CO., INC. (US) 1997-08-07 WO disclosed