Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 11/20 | 0.48 |
| ▸ | PPARG | P37231 | 9/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559854 | 0.78 | GRM2 (0.38) | GRM2PPARGPPARAPPARD | |
| SCHEMBL6560541 | 0.71 | HTR2C (0.36) | GRM2 | |
| SCHEMBL10637215 | 0.69 | SMN1; SMN2 (0.38) | GRM2PPARGPPARAPPARD | |
| SCHEMBL18362160 | 0.69 | HTR6 (0.48) | GRM2PPARGPPARAPPARD | |
| SCHEMBL1998937 | 0.68 | GRM2 (0.66) | GRM2PPARGPPARAPPARD | |
| SCHEMBL2001590 | 0.68 | GRM2 (0.61) | GRM2 | |
| SCHEMBL6935925 | 0.68 | CYP1A2 (0.49) | GRM2PPARGPPARAPPARD | |
| SCHEMBL20655557 | 0.67 | HTR6 (0.46) | PPARGPPARAPPARD | |
| SCHEMBL6560593 | 0.65 | PPARA (0.60) | PPARGPPARAPPARD | |
| SCHEMBL6936012 | 0.65 | CYSLTR2 (0.54) | GRM2PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |