Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14497609 | 1.00 | KCNH2 (0.61) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL14497610 | 1.00 | KCNH2 (0.61) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL6560821 | 0.91 | KCNH2 (0.52) | KCNH2OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL6560052 | 0.88 | KCNH2 (0.50) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL15154321 | 0.87 | KCNH2 (0.49) | KCNH2OPRM1OPRD1OPRK1 | |
| SCHEMBL15154101 | 0.85 | SIGMAR1 (0.48) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL19617488 | 0.79 | KCNH2 (0.61) | KCNH2OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL14497613 | 0.79 | KCNH2 (0.61) | KCNH2OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL14497614 | 0.79 | KCNH2 (0.61) | KCNH2OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL28644761 | 0.78 | KCNH2 (0.42) | KCNH2BACE1BACE2CTSDPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112625153-A | Catalyst component for olefin polymerization, preparation method, catalyst and application thereof | 中国石油化工股份有限公司 | 2021-04-09 | — | — | CN | claimed |
| EP-3458439-B1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | ALERE SAN DIEGO INC (US) | 2021-12-08 | — | — | EP | disclosed |
| US-11192857-B2 | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use | ALERE SAN DIEGO, INC. (US) | 2021-12-07 | — | — | US | disclosed |
| CN-112625153-A | Catalyst component for olefin polymerization, preparation method, catalyst and application thereof | 中国石油化工股份有限公司 | 2021-04-09 | — | — | CN | disclosed |
| US-20190292148-A1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | ALERE SAN DIEGO, INC. (US) | 2019-09-26 | — | — | US | disclosed |
| EP-3458439-A1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | Alere San Diego, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017201314-A1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | ALERE SAN DIEGO, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| EP-0931062-B1 | CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE | MICROGENICS CORP (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-0931062-A1 | CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE | MICROGENICS CORPORATION (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998054133-A1 | CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE | MICROGENICS CORPORATION (US) | 1998-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11192857-B2 | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use | DPYSL2, DNPEP, DPYSL3 | KCNH2 4297/4885BACE1 3051/4885BACE2 1749/4885 |
| US-20190292148-A1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | DPYSL2, DNPEP, DPYSL3 | KCNH2 4297/4885BACE1 3051/4885BACE2 1749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.