Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561883 | 1.00 | KCNH2 (0.61) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL14497610 | 1.00 | KCNH2 (0.61) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL6560821 | 0.91 | KCNH2 (0.52) | KCNH2OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL6560052 | 0.88 | KCNH2 (0.50) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL15154321 | 0.87 | KCNH2 (0.49) | KCNH2OPRM1OPRD1OPRK1 | |
| SCHEMBL15154101 | 0.85 | SIGMAR1 (0.48) | KCNH2BACE1BACE2CTSDPRMT5 | |
| SCHEMBL19617488 | 0.79 | KCNH2 (0.61) | KCNH2OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL14497613 | 0.79 | KCNH2 (0.61) | KCNH2OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL14497614 | 0.79 | KCNH2 (0.61) | KCNH2OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL28644761 | 0.78 | KCNH2 (0.42) | KCNH2BACE1BACE2CTSDPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230017786-A1 | DEXTROMETHADONE AS A DISEASE-MODIFYING TREATMENT FOR NEUROPSYCHIATRIC DISORDERS AND DISEASES | MANFREDI, PAOLO L. | 2023-01-19 | — | — | US | disclosed |
| US-20070129434-A1 | Analgesics and methods of use | ENDO PHARMACEUTICALS INC. | 2007-06-07 | — | — | US | disclosed |
| US-20070129434-A1 | Analgesics and methods of use | ENDO PHARMACEUTICALS INC. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230017786-A1 | DEXTROMETHADONE AS A DISEASE-MODIFYING TREATMENT FOR NEUROPSYCHIATRIC DISORDERS AND DISEASES | COMT, TPMT, DRD2 | KCNH2 2531/4885BACE1 1312/4885BACE2 2255/4885 |
| US-20070129434-A1 | Analgesics and methods of use | OPRD1, OPRM1, OPRK1 | KCNH2 2089/4885BACE1 3179/4885BACE2 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.