Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.53 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.53 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | RORA | P35398 | 1/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7247986 | 0.84 | ABCC9 (0.45) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8657172 | 0.84 | ABCC9 (0.45) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL31211576 | 0.83 | KMT2A (0.57) | KMT2ANR1H3NR1H2MEN1NR1I2 | |
| SCHEMBL8657904 | 0.82 | ABCC9 (0.47) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| Dimethylamine SCHEMBL6569138 | 0.79 | ABCC9 (0.44) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8656072 | 0.79 | ABCC9 (0.44) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6569133 | 0.78 | ABCC9 (0.44) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7253590 | 0.78 | ABCC9 (0.41) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7247433 | 0.78 | ABCC9 (0.44) | KMT2AABCC9ABCC8KCNJ11KCNJ8 | |
| Dimethylamine SCHEMBL6571779 | 0.77 | ABCC9 (0.43) | KMT2AABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214296-B1 | SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |