Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29662920 | 1.00 | ESR2 (0.50) | ESR2ARTSHRCYP11B2TRPA1 | |
| SCHEMBL21188814 | 0.81 | TSHR (0.55) | ESR2ARTSHRCYP11B2TRPA1 | |
| SCHEMBL22115307 | 0.80 | CYP11B2 (0.52) | ESR2ARCYP11B2TRPA1HSD17B3 | |
| SCHEMBL1372803 | 0.80 | ALOX5AP (0.52) | ESR2ARTSHRCYP11B2TRPA1 | |
| SCHEMBL1873 | 0.80 | ESR2 (0.50) | ESR2ARTSHRTRPA1CYP1A2 | |
| SCHEMBL15354395 | 0.78 | TNKS2 (0.53) | ARTRPA1CYP3A4 | |
| SCHEMBL6564002 | 0.78 | AR (0.55) | ESR2ARTSHRCYP11B2TRPA1 | |
| SCHEMBL20405268 | 0.77 | ESR2 (0.63) | ESR2ARTSHRTRPA1CYP1A2 | |
| SCHEMBL1893259 | 0.76 | ESR2 (0.46) | ESR2ARTSHRCYP11B2TRPA1 | |
| SCHEMBL6562156 | 0.76 | AR (0.65) | ESR2ARCYP11B2TRPA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223158-B1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | BAYER CHEMICALS AG (DE) | 2004-08-11 | — | — | EP | disclosed |
| US-6580002-B2 | Dihalo-, cyano- and methyl- substituted biphenyl chemical intermediates | BAYER AKTIENGESELLSCHAFT (DE) | 2003-06-17 | — | — | US | disclosed |
| US-20030055285-A1 | Process for the preparation of trifiuoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles | LANXESS DEUTSCHLAND GMBH (DE) | 2003-03-20 | — | — | US | disclosed |
| US-6465688-B2 | CONVERTING METHYL-SUBSTITUTED BIPHENYLCARBONITRILES TO A TRICHLOROMETHYL- AND HYDROLYZING TO CORRESPONDING CARBOXY ACIDS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-15 | — | — | US | disclosed |
| US-20020095052-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL-SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS AND NOVEL TRICHLOROMETHYL - AND TRIFLUOROMETHYL - SUBSTITUTED BIPHENYLCARBONITRILES | LANXESS DEUTSCHLAND GMBH (DE) | 2002-07-18 | — | — | US | disclosed |
| EP-1223158-A1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | Bayer Aktiengesellschaft (DE) | 2002-07-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055285-A1 | Process for the preparation of trifiuoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles | CPSF1, CYP2F1, CYP4F2 | ESR2 3683/4885AR 3863/4885TSHR 2774/4885 |
| US-20020095052-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL-SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS AND NOVEL TRICHLOROMETHYL - AND TRIFLUOROMETHYL - SUBSTITUTED BIPHENYLCARBONITRILES | MCCC2, CYP2F1, CYP4F2 | ESR2 2903/4885AR 3119/4885TSHR 2802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.