Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 14/20 | 0.62 |
| ▸ | METAP1 | P53582 | 8/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564948 | 0.86 | METAP2 (0.66) | METAP2METAP1ATM | |
| SCHEMBL6476924 | 0.80 | METAP2 (0.63) | METAP2METAP1ATM | |
| SCHEMBL6477146 | 0.80 | METAP2 (0.70) | METAP2METAP1LTA4H | |
| SCHEMBL6489285 | 0.79 | METAP2 (0.56) | METAP2METAP1ATMMMP1MMP2 | |
| SCHEMBL6478070 | 0.79 | METAP2 (0.62) | METAP2METAP1ATM | |
| SCHEMBL6484981 | 0.79 | METAP2 (0.62) | METAP2METAP1ATM | |
| SCHEMBL6477581 | 0.79 | METAP2 (0.62) | METAP2METAP1ATM | |
| SCHEMBL6486417 | 0.79 | METAP2 (0.62) | METAP2METAP1ATM | |
| SCHEMBL6487882 | 0.79 | METAP2 (0.62) | METAP2METAP1ATM | |
| SCHEMBL7353859 | 0.79 | METAP2 (0.65) | METAP2METAP1MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | claimed |