Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563540 | 0.82 | GPR27 (0.35) | LMNATSHRALDH1A1MAPTKMT2A | |
| SCHEMBL6565466 | 0.82 | HPGD (0.38) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL8137124 | 0.75 | TSHR (0.50) | SMN1; SMN2LMNAMAPK1TSHRL3MBTL1 | |
| SCHEMBL20138852 | 0.75 | KMT2A (0.49) | HSD11B1SMN1; SMN2LMNAMAPK1L3MBTL1 | |
| SCHEMBL6565337 | 0.74 | CHRNA1 (0.38) | SMN1; SMN2LMNATSHRALDH1A1HPGD | |
| SCHEMBL6565431 | 0.70 | CHRNA1 (0.36) | SMN1; SMN2LMNATSHRALDH1A1MAPT | |
| SCHEMBL3611806 | 0.70 | ESR1 (0.54) | HSD11B1SMN1; SMN2LMNAMAPK1TSHR | |
| SCHEMBL26601824 | 0.70 | NOTUM (0.37) | TSHRMAPTKMT2ANPSR1HPGD | |
| SCHEMBL4626852 | 0.70 | TSHR (0.52) | SMN1; SMN2LMNAMAPK1TSHRL3MBTL1 | |
| SCHEMBL24633176 | 0.68 | TSHR (0.50) | SMN1; SMN2LMNAMAPK1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |