Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611806 | 0.86 | ESR1 (0.54) | KMT2AMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL6401663 | 0.84 | HSD11B1 (0.57) | KMT2AMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL6153059 | 0.84 | KMT2A (0.48) | KMT2AMAPTALDH1A1HPGDLMNA | |
| SCHEMBL14319712 | 0.80 | HSD11B1 (0.50) | KMT2AMAPTALDH1A1HPGDLMNA | |
| SCHEMBL3610735 | 0.77 | POLB (0.46) | KMT2AMAPTALDH1A1MEN1HSD11B1 | |
| SCHEMBL20143674 | 0.76 | ALDH1A1 (0.50) | KMT2AMAPTALDH1A1HPGDLMNA | |
| SCHEMBL3615238 | 0.76 | MAOB (0.55) | KMT2AMAPTALDH1A1LMNAMEN1 | |
| SCHEMBL21991807 | 0.75 | KMT2A (0.45) | KMT2AMAPTALDH1A1HPGDLMNA | |
| SCHEMBL12981985 | 0.75 | ELANE (0.46) | KMT2AMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL6563239 | 0.75 | HSD11B1 (0.39) | KMT2AMAPTALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |