Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10520281 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1538972 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1538821 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28671040 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL396600 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL1854489 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL11435761 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL150719 | 1.00 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28410687 | 0.97 | TSHR (0.53) | TSHRTHRBDNM1ALDH1A1LMNA | |
| SCHEMBL1232118 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4012566-A | CONTACTING WITH A HOMOGENEOUS OLEFIN DISPROPORTIONATION CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1977-03-15 | — | — | US | claimed |
| EP-0640627-B1 | Ethylene-alpha-olefin copolymers and molded article thereof | SUMITOMO CHEMICAL CO (JP) | 2004-03-31 | — | — | EP | disclosed |
| CN-1069094-C | Process for producing lanthanide metal carboxylate | QIMEI IND CO LTD (CN) | 2001-08-01 | — | — | CN | disclosed |
| EP-0968992-A1 | Process for producing lanthanide series metal corboxylates and their use for the polymerization of diene monomers | Chi Mei Corporation (TW) | 2000-01-05 | — | — | EP | disclosed |
| CN-1230536-A | Process for producing lanthanide metal carboxylate | QIMEI IND CO LTD (CN) | 1999-10-06 | — | — | CN | disclosed |
| EP-0652240-B1 | Process for polybutadiene production using catalyst with high activity | BAYER INC (CA) | 1998-01-28 | — | — | EP | disclosed |
| US-5700895-A | MOLDING MATERIALS; HIGH MELT TENSION, TRANSPARENCY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-12-23 | — | — | US | disclosed |
| US-5428119-A | A mixture of neodymium carboxylate, an alkyl aluminum chloride and an alkyl aluminum hydride | POLYSAR RUBBER CORPORATION (CA) | 1995-06-27 | — | — | US | disclosed |
| EP-0652240-A1 | Process for polybutadiene production using catalyst with high activity | BAYER RUBBER INC. (CA) | 1995-05-10 | — | — | EP | disclosed |
| EP-0640627-A1 | Ethylene-alpha-olefin copolymers and molded article thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-4578374-A | Polymerization catalyst, production and use | EXXON RESEARCH & ENGINEERING CO. (US) | 1986-03-25 | — | — | US | disclosed |
| EP-0174102-A1 | Polymerization catalyst, production and use | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1986-03-12 | — | — | EP | disclosed |
| EP-0174104-A1 | Polymerization catalyst, production and use | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1986-03-12 | — | — | EP | disclosed |
| EP-0173488-A1 | Polymerization catalyst, production and use | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1986-03-05 | — | — | EP | disclosed |
| EP-0173487-A1 | Polymerization catalyst, production and use | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1986-03-05 | — | — | EP | disclosed |
| US-4558025-A | COORDINATION CATALYST | EXXON RESEARCH & ENGINEERING CO. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4558024-A | COORDINATION CATALYST | EXXON RESEARCH & ENGINEERING CO. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4471066-A | Polymerization of olefins | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1984-09-11 | — | — | US | disclosed |
| EP-0058549-A2 | Catalyst for polymerization of olefins | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-08-25 | — | — | EP | disclosed |
| US-4012566-A | CONTACTING WITH A HOMOGENEOUS OLEFIN DISPROPORTIONATION CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1977-03-15 | — | — | US | disclosed |