SCHEMBL6563887

SCHEMBL6563887

CC(C)(C)[Si](C)(C)OCc1ccc(OCc2cc(Br)cs2)cc1CO[Si](C)(C)C(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MGMT P16455 4/20 0.35
GAA P10253 1/20 0.33
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
RAB9A P51151 1/20 0.31
ATM Q13315 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL216403 0.84 MGMT (0.38) MGMTGAA
SCHEMBL6563146 0.83 BACE1 (0.33) RAB9AL3MBTL1
SCHEMBL7649567 0.83
SCHEMBL6563085 0.81 CA2 (0.30)
SCHEMBL7616233 0.81 LTA4H (0.34)
SCHEMBL6563010 0.81 MAPT (0.33) GAARAB9A
SCHEMBL7606423 0.80
SCHEMBL6889630 0.78
SCHEMBL6562766 0.78
SCHEMBL6889628 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1235824-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2004-05-19 EP disclosed
US-6706725-B1 BIAROMATIC COMPOUNDS WHICH ARE VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2004-03-16 US disclosed
EP-1235824-A1 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2002-09-04 EP disclosed
WO-2001038320-A1 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2001-05-31 WO disclosed