Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.49 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.48 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589336 | 0.88 | KMT2A (0.50) | DTYMKKMT2APOLBKIF18AABCC9 | |
| SCHEMBL8625649 | 0.82 | ABCC9 (0.45) | KMT2APOLBKIF18AABCC9ABCC8 | |
| SCHEMBL7322857 | 0.82 | DTYMK (0.58) | DTYMKKMT2APOLBGAAMEN1 | |
| SCHEMBL2903871 | 0.81 | KMT2A (0.56) | KMT2APOLBKIF18AABCC9ABCC8 | |
| SCHEMBL1625062 | 0.81 | DTYMK (0.57) | DTYMKKMT2APOLBMEN1SLC25A1 | |
| SCHEMBL28969126 | 0.81 | DTYMK (0.57) | DTYMKKMT2APOLBGAAMEN1 | |
| SCHEMBL11030600 | 0.81 | DTYMK (0.57) | DTYMKKMT2APOLBMEN1SLC25A1 | |
| SCHEMBL5426543 | 0.80 | APEX1 (0.64) | KMT2APOLBSLC16A1MEN1MAPT | |
| SCHEMBL29435082 | 0.80 | APEX1 (0.64) | KMT2APOLBSLC16A1MEN1MAPT | |
| SCHEMBL1296081 | 0.80 | APEX1 (0.64) | KMT2APOLBSLC16A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| EP-0625511-B1 | Heterocyclic compounds and their use in pharmaceutical | ZENECA LTD (GB) | 1999-02-17 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |
| US-5504089-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1996-04-02 | — | — | US | disclosed |
| EP-0625511-A1 | Heterocyclic compounds and their use in pharmaceutical | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |