Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 2/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PROC | P04070 | 1/20 | 0.34 |
| ▸ | HPN | P05981 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.34 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563712 | 0.87 | PLAU (0.47) | PPARGPLAUPOLBEGLN1 | |
| SCHEMBL6565182 | 0.86 | PPARG (0.41) | PPARGTP53PRMT5MAPTALDH1A1 | |
| SCHEMBL6561967 | 0.86 | F2 (0.42) | PLAUTP53PRMT5NQO2SLC22A2 | |
| SCHEMBL6563517 | 0.76 | F2 (0.45) | PLAUNQO2SLC22A2F2F10 | |
| SCHEMBL6762415 | 0.75 | NOTUM (0.40) | PLAUNQO2SLC22A2F2F10 | |
| SCHEMBL6562343 | 0.74 | F2 (0.54) | NQO2SLC22A2F2F10PLG | |
| SCHEMBL6565497 | 0.74 | PLAU (0.48) | PLAUF2PRSS1PRSS2PRSS3 | |
| SCHEMBL6565956 | 0.73 | PLAU (0.49) | PLAUF2F10PLGPLAT | |
| SCHEMBL6563622 | 0.72 | KMT2A (0.43) | PPARGPOLBMEN1KMT2AEGLN1 | |
| SCHEMBL6562387 | 0.72 | NQO2 (0.51) | TP53NQO2SLC22A2F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |