Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565295 | 0.87 | PPARG (0.36) | PLAUPPARGPOLBEGLN1 | |
| SCHEMBL6565956 | 0.85 | PLAU (0.49) | PLAUITGB3ITGA2BEGFRERBB2 | |
| SCHEMBL6563622 | 0.85 | KMT2A (0.43) | PPARGGRM5EGFRERBB2POLB | |
| SCHEMBL6565497 | 0.84 | PLAU (0.48) | PLAUSIRT2TSHR | |
| SCHEMBL7672235 | 0.78 | PLAU (0.49) | PLAUITGB3ITGA2BPPARGEGFR | |
| SCHEMBL6565392 | 0.77 | PLAU (0.44) | PLAUITGB3ITGA2BSIRT2 | |
| SCHEMBL6563250 | 0.75 | PLAU (0.54) | PLAUITGB3ITGA2BSIRT2 | |
| SCHEMBL6565690 | 0.75 | PLAU (0.54) | PLAUITGB3ITGA2BSIRT2 | |
| SCHEMBL6565486 | 0.74 | PLAU (0.41) | PLAUITGB3ITGA2BSIRT2TSHR | |
| SCHEMBL6565182 | 0.72 | PPARG (0.41) | PPARGEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |