Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.55 |
| ▸ | THRA | P10827 | 9/20 | 0.54 |
| ▸ | THRB | P10828 | 9/20 | 0.54 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | ASPH | Q12797 | 1/20 | 0.51 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.51 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565865 | 0.92 | EGLN1 (0.57) | EGLN1THRATHRBFTO | |
| SCHEMBL1509109 | 0.90 | EGLN1 (0.64) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL8633329 | 0.88 | EGLN1 (0.54) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL8628981 | 0.87 | EGLN1 (0.55) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL8625460 | 0.87 | EGLN1 (0.55) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL8629876 | 0.86 | EGLN1 (0.51) | EGLN1THRATHRBFTO | |
| SCHEMBL6567197 | 0.85 | EGLN1 (0.55) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL8629988 | 0.82 | EGLN1 (0.48) | EGLN1THRATHRBFTO | |
| SCHEMBL6564111 | 0.82 | MTNR1B (0.48) | — | |
| SCHEMBL705929 | 0.81 | EGLN1 (0.62) | EGLN1THRATHRBBBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |