Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.48 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629876 | 0.91 | EGLN1 (0.51) | EGLN1THRATHRBFTOHIF1AN | |
| SCHEMBL8630076 | 0.90 | EGLN1 (0.45) | EGLN1THRATHRBALDH1A1 | |
| SCHEMBL6565865 | 0.89 | EGLN1 (0.57) | EGLN1THRATHRBKDM4EALDH1A1 | |
| SCHEMBL8628533 | 0.89 | POLB (0.45) | EGLN1FTOHIF1AN | |
| SCHEMBL8625366 | 0.88 | EGLN1 (0.44) | EGLN1ALDH1A1 | |
| SCHEMBL8751144 | 0.88 | EGLN1 (0.44) | EGLN1ALDH1A1 | |
| SCHEMBL6564105 | 0.88 | EGLN1 (0.48) | EGLN1FTOHIF1AN | |
| SCHEMBL8628487 | 0.87 | EGLN1 (0.50) | EGLN1FTOHIF1AN | |
| SCHEMBL6567419 | 0.86 | EGLN1 (0.51) | EGLN1FTOHIF1AN | |
| SCHEMBL8629264 | 0.86 | EGLN1 (0.51) | EGLN1FTOHIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |