SCHEMBL6565488

SCHEMBL6565488

FC(F)(F)c1ccccc1C(Cl)(Cl)Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
TDP1 Q9NUW8 2/20 0.44
POLB P06746 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
IDO1 P14902 2/20 0.41
TSHR P16473 2/20 0.41
HSD11B1 P28845 2/20 0.40
LMNA P02545 2/20 0.40
GAA P10253 1/20 0.40
NFKB1 P19838 1/20 0.39
KIF11 P52732 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ATM Q13315 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
P2RX7 Q99572 1/20 0.38
HTR2C P28335 1/20 0.38
CA2 P00918 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL545083 0.87 TSHR (0.50) ALDH1A1TDP1TSHRLMNACA2
SCHEMBL30318973 0.87 TSHR (0.50) ALDH1A1TDP1TSHRLMNACA2
SCHEMBL29441997 0.87 ALDH1A1 (0.52) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL63469 0.87 ALDH1A1 (0.52) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL6566306 0.86 TSHR (0.48) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL11724304 0.86 TSHR (0.39) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL11722237 0.86 ALDH1A1 (0.43) ALDH1A1TDP1POLBL3MBTL1IDO1
SCHEMBL11724773 0.86 ALDH1A1 (0.43) ALDH1A1TDP1POLBL3MBTL1IDO1
Benzene SCHEMBL21048983 0.84 TSHR (0.56) ALDH1A1TDP1TSHRLMNACYP1A2
Hydrogen Sulfide SCHEMBL28274662 0.84 ALDH1A1 (0.50) ALDH1A1TDP1POLBL3MBTL1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100500631-C Process of preparing 3-trifluoromethyl benzoic acid SHANGHAI KANGPENG CHEMISTRY CO (CN) 2009-06-17 CN claimed
CN-100500637-C Preparation process of 3-trifluoro methyl benzoate SHANGHAI KANGPENG CHEMISTRY CO (CN) 2009-06-17 CN claimed
CN-101066926-A Prepn process of 3-trifluoro methyl benzoate SHANGHAI KANGPENG CHEMISTRY CO (CN) 2007-11-07 CN claimed
CN-101066917-A Process of preparing 3-trifluoromethyl benzoic acid SHANGHAI KANGPENG CHEMISTRY CO (CN) 2007-11-07 CN claimed
EP-0953557-B1 Method for producing bis(trifluoromethyl)benzene CENTRAL GLASS CO LTD (JP) 2004-03-31 EP claimed
WO-2001079148-A2 METHOD OF MAKING BENZOYL HALIDES AND NITRILES AMERICAN WRECKING CORPORATION OF NEW JERSEY (US) 2001-10-25 WO claimed
US-6093858-A Method for producing bis (trifluoromethyl) benzene CENTRAL GLASS COMPANY, LIMITED (JP) 2000-07-25 US claimed
EP-0953557-A1 Method for producing bis(trifluoromethyl)benzene Central Glass Company, Limited (JP) 1999-11-03 EP claimed
US-4296244-A (3-Trifluoromethylphenyl)-alpha-hydroxyacetic acid and process for preparation HOOKER CHEMICALS & PLASTICS CORP. (US) 1981-10-20 US claimed
US-4268687-A Method of making methyl and ethyl esters of (3-trifluoromethylphenyl)-acetic acid HOOKER CHEMICALS & PLASTICS CORP. (US) 1981-05-19 US claimed
US-4238413-A (3-Trifluoromethyl)-benzoyl cyanide and process for its production HOOKER CHEMICALS & PLASTICS CORP. (US) 1980-12-09 US claimed
US-4183873-A WITH HYDROGEN FLUORIDE IN THE PRESENCE OF MOLYBDENUM PENTACHLORIDE CATALYST HOOKER CHEMICALS & PLASTICS CORP. (US) 1980-01-15 US claimed
US-4093669-A HALOGEN TRANSFER CATALYST BAYER AKTIENGESELLSCHAFT (DT) 1978-06-06 US claimed
US-4079089-A CONTACTING A BIS/TRICHLOROMETHYL/-BENZENE WITH HYDROGEN FLUORIDE, HALOGEN TRANSFER CATALYST BAYER AKTIENGESELLSCHAFT (DT) 1978-03-14 US claimed
JP-11310542-A None JP disclosed
CN-107417518-A To trifluoromethylbenzoic acid synthetic method between a kind of neighbour 淄博飞源化工有限公司 2017-12-01 CN disclosed
CN-100500637-C Preparation process of 3-trifluoro methyl benzoate SHANGHAI KANGPENG CHEMISTRY CO (CN) 2009-06-17 CN disclosed
US-4079089-A CONTACTING A BIS/TRICHLOROMETHYL/-BENZENE WITH HYDROGEN FLUORIDE, HALOGEN TRANSFER CATALYST BAYER AKTIENGESELLSCHAFT (DT) 1978-03-14 US disclosed
US-4079090-A Preparation of trichloromethyl-trifluoro methyl-benzenes BAYER AKTIENGESELLSCHAFT (DT) 1978-03-14 US disclosed
US-4079089-A CONTACTING A BIS/TRICHLOROMETHYL/-BENZENE WITH HYDROGEN FLUORIDE, HALOGEN TRANSFER CATALYST BAYER AKTIENGESELLSCHAFT (DT) 1978-03-14 US disclosed