SCHEMBL6565595

SCHEMBL6565595

O=c1oc(-c2ccc3cc(-c4nc5ccc(Br)cc5c(=O)o4)ccc3c2)nc2ccc(Br)cc12

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.65
MAPT P10636 5/20 0.61
RAB9A P51151 5/20 0.60
NPC1 O15118 5/20 0.60
RXFP1 Q9HBX9 1/20 0.60
ALDH1A1 P00352 7/20 0.59
KDM4E B2RXH2 6/20 0.59
KMT2A Q03164 4/20 0.59
HPGD P15428 4/20 0.59
MEN1 O00255 3/20 0.59
CYP1A2 P05177 1/20 0.59
CYP2C19 P33261 1/20 0.59
HSD17B10 Q99714 1/20 0.48
ELANE P08246 1/20 0.47
HPN P05981 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
POLB P06746 1/20 0.47
PTK2B Q14289 1/20 0.47
F2 P00734 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6565665 0.92 TP53 (0.70) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL2843939 0.86 NPC1 (0.70) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL914528 0.84 KDM4E (0.61) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL26170015 0.83 TP53 (0.55) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL30893109 0.82 ALDH1A1 (0.70) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL18131027 0.82 ALDH1A1 (0.70) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL6563950 0.82 ALDH1A1 (0.59) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL6565915 0.82 MAPT (0.68) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL6564042 0.82 MAPT (0.48) TP53MAPTRAB9ANPC1RXFP1
SCHEMBL6567424 0.82 ELANE (0.62) TP53MAPTRAB9ANPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0993965-B1 Thermally sensitive recording medium JUJO PAPER CO LTD (JP) 2004-03-31 EP disclosed
US-6440897-B1 BIS-BENZOXAZINONE COMPOUND AS AN ULTRAVIOLET RAY ABSORBING AGENT NIPPON PAPER INDUSTRIES CO LTD (JP) 2002-08-27 US disclosed
EP-0993965-A2 Thermally sensitive recording medium NIPPON PAPER INDUSTRIES CO., LTD. (JP) 2000-04-19 EP disclosed