Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 5/20 | 0.36 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | BHMT | Q93088 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPY4R | P50391 | 3/20 | 0.32 |
| ▸ | NPY1R | P25929 | 2/20 | 0.32 |
| ▸ | NPY2R | P49146 | 2/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL6565605 | 1.00 | OTC (0.38) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Arginine SCHEMBL6437080 | 0.96 | CYP1A2 (0.38) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Arginine SCHEMBL6437076 | 0.96 | CYP1A2 (0.38) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Arginine SCHEMBL6433284 | 0.94 | OTC (0.42) | OTCNOS2NOS3NOS1DDAH1 | |
| Arginine SCHEMBL6433292 | 0.94 | OTC (0.42) | OTCNOS2NOS3NOS1DDAH1 | |
| Arginine SCHEMBL6567386 | 0.94 | ALOX15 (0.39) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Arginine SCHEMBL9188925 | 0.92 | PTGS1 (0.44) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Arginine SCHEMBL5078038 | 0.92 | PTGS1 (0.44) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Arginine SCHEMBL9188915 | 0.92 | PTGS1 (0.44) | OTCPTGS1SLC7A11NOS2NOS3 | |
| Arginine SCHEMBL27620474 | 0.91 | ALOX15 (0.36) | OTCPTGS1SLC7A11NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399147-A2 | THERAPEUTIC DELIVERY OF CARBON MONOXIDE | Northwick Park Institute For Medical Research (GB) | 2004-03-24 | — | — | EP | claimed |
| WO-2002092075-A2 | THERAPEUTIC DELIVERY OF CARBON MONOXIDE | NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH (GB) | 2002-11-21 | — | — | WO | claimed |