Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL6567386 | 0.97 | ALOX15 (0.39) | ALOX15BLMPMP22KMT2AGRM8 | |
| Arginine SCHEMBL6437076 | 0.95 | CYP1A2 (0.38) | ALOX15BLMPMP22KMT2AGRM8 | |
| Arginine SCHEMBL6437080 | 0.95 | CYP1A2 (0.38) | ALOX15BLMPMP22KMT2AGRM8 | |
| Arginine SCHEMBL7036397 | 0.91 | ENPEP (0.33) | ALOX15BLMPMP22KMT2AGRM8 | |
| Arginine SCHEMBL6565610 | 0.91 | OTC (0.38) | ALOX15BLMPMP22KMT2ACYP1A2 | |
| Arginine SCHEMBL1835280 | 0.91 | ALOX15 (0.44) | ALOX15BLMPMP22KMT2AGRM8 | |
| Arginine SCHEMBL1835278 | 0.91 | ALOX15 (0.44) | ALOX15BLMPMP22KMT2AGRM8 | |
| Arginine SCHEMBL6565605 | 0.91 | OTC (0.38) | ALOX15BLMPMP22KMT2ACYP1A2 | |
| Arginine SCHEMBL27848013 | 0.88 | ALOX15 (0.47) | ALOX15BLMPMP22KMT2AGRM8 | |
| Arginine SCHEMBL6435765 | 0.87 | GLP1R (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1742997-A | Mimetics of interleukin-8 and use of them in the prevention, treatment, diagnosis of a disease | CHEMOKINE THERAPEUTICS CORP (CA) | 2006-03-08 | — | — | CN | disclosed |