SCHEMBL6565868

SCHEMBL6565868

CCc1c(C)cccc1[C@@H]1c2c(C)c(N3Cc4cc(OC)c(OC)cc4C3)c(C)c(C)c2OC1(C)C

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PDE10A Q9Y233 1/20 0.31
ACHE P22303 1/20 0.30
ADRA1B P35368 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
ALOX15 P16050 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5109954 0.81 MAPT (0.35) MEN1KMT2APDE10A
SCHEMBL5109965 0.81 MAPT (0.35) MEN1KMT2APDE10A
SCHEMBL2778461 0.81 KMT2A (0.36) ABCB1MEN1KMT2AACHE
Hydrochloric Acid SCHEMBL4821106 0.80 BCHE (0.31) ACHEKDM4EALDH1A1
SCHEMBL6565871 0.79 ABCC1 (0.33) ACHE
SCHEMBL1269359 0.79 TLR4 (0.35) PDE10AACHEALDH1A1
SCHEMBL2905278 0.79 TLR4 (0.35) PDE10AACHEALDH1A1
SCHEMBL29567882 0.79 TLR4 (0.35) PDE10AACHEALDH1A1
Bromide SCHEMBL2910934 0.78 TLR4 (0.34) PDE10AALDH1A1
Hydrochloric Acid SCHEMBL2912744 0.78 TLR4 (0.34) PDE10AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1457207-A1 SOLID COMPOSITIONS CONTAINNG COMPOUNDS UNSTABLE TO OXYGEN AND METHOD FOR STABILIZATION THEREOF Takeda Chemical Industries, Ltd. (JP) 2004-09-15 EP disclosed