Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563731 | 0.93 | CXCR2 (0.53) | CXCR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6565699 | 0.85 | VCAM1 (0.45) | CXCR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6565841 | 0.82 | VCAM1 (0.43) | CXCR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6563448 | 0.82 | ALDH1A1 (0.47) | CXCR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6564043 | 0.81 | CXCR2 (0.41) | CXCR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6564230 | 0.81 | VCAM1 (0.48) | CXCR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6563456 | 0.78 | VCAM1 (0.64) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL27571698 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL6564278 | 0.78 | VCAM1 (0.60) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL6565613 | 0.78 | ALDH1A1 (0.45) | CXCR2ALDH1A1MAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161232-B1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-03-24 | — | — | EP | disclosed |
| US-6500863-B1 | INTERLEUKIN BINDING INHIBITORS SUCH AS N-(2-HYDROXYL-3-AMINO SULFONYL-4-CHLOROPHENYL)-N'-(2-BROMOPHENYL)UREA, USED FOR PROPHYLAXIS OF CHEMOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2002-12-31 | — | — | US | disclosed |