⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631191 | 0.89 | CNR2 (0.38) | — | |
| SCHEMBL6565698 | 0.83 | EGLN1 (0.40) | — | |
| SCHEMBL6566153 | 0.77 | — | — | |
| SCHEMBL6565252 | 0.77 | EGLN1 (0.41) | — | |
| SCHEMBL8629531 | 0.71 | MRGPRX4 (0.44) | — | |
| SCHEMBL6566146 | 0.70 | MRGPRX4 (0.41) | — | |
| SCHEMBL6566297 | 0.70 | KMT2A (0.43) | — | |
| SCHEMBL8625570 | 0.70 | MAPT (0.45) | — | |
| SCHEMBL8751176 | 0.67 | CYP1A2 (0.39) | — | |
| SCHEMBL6567446 | 0.64 | EGLN1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |