Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 14/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566149 | 0.89 | — | — | |
| SCHEMBL6565235 | 0.82 | EGLN1 (0.43) | KDM5B | |
| SCHEMBL8629531 | 0.81 | MRGPRX4 (0.44) | ALDH1A1HTTCYP1A2CYP2C9MRGPRX4 | |
| Tetrahydrofuran SCHEMBL8630504 | 0.76 | EGLN1 (0.38) | CNR2KDM5B | |
| SCHEMBL6565252 | 0.74 | EGLN1 (0.41) | KDM5B | |
| SCHEMBL6565698 | 0.72 | EGLN1 (0.40) | KDM5B | |
| SCHEMBL8630305 | 0.72 | MRGPRX4 (0.44) | MRGPRX4 | |
| SCHEMBL6564220 | 0.71 | MRGPRX4 (0.41) | ALDH1A1HTTCYP1A2CYP2C9MRGPRX4 | |
| SCHEMBL2715191 | 0.68 | MRGPRX4 (0.53) | ALDH1A1MEN1MAPTHTTKMT2A | |
| SCHEMBL16711868 | 0.67 | ALDH1A1 (0.44) | CNR2ALDH1A1MEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |